News

A warning for the potential interaction between the directly acting anti-hepatitis C drug dasabuvir and clopidogrel was recently issued. It has been found that clopidogrel is converted to a strong inhibitor of P 450 CYP2C8 via glucoronidation. Dasabuvir is a...

FDA has issued a drug safety communication on the combination of sofosbuvir and the antiarrhythmic drug amiodarone. One case of fatal cardiac arrest and three cases of severe bradycardia requiring pacemaker placement to regulate their heart rhythms have been...

18 HIV-infected HSV-2 negative individuals with more than 500 CD4-cells not yet on ART were included in a double blind placebo-controlled crossover study of valacyclovir. Participants were given...

Coffee consumption has been associated with beneficial effects on cirrhosis progression and cancer development in several studies including chronic HCV infection. The in vitro effect of caffeine on hepatitis C was evaluated in a Brazilian study. A full length HCV 2...

The “Opposites Attract study” is a prospective observational study in serodiscordant gay couples in Australia, Thailand and Brazil. Preliminary results were presented at CROI in February. By December...

Dolutegravir has shown in vitro activity against HIV-2. Thirteen heavily pretreated HIV-2 infected French patients failing on a regimen including raltegravir were treated with combinations including dolutegravir in a dose of 50 mg BID. The patients had a median...

64 Egyptian infants born to HBsAg positive mothers received vaccination and hepatitis B immunoglobulin within 48 hours after birth. At least one month after the last vaccination and not earlier than at 6 months of age the infants were tested for HBV serological...

Almost six thousand HIV-positive individuals attending an HIV/ AIDS care program in Uganda from 2002 to 2013 were evaluated for the occurrence of five different opportunistic infections. More than 200 000 monthly medical reports were analyzed. During the study...

22 pregnant women received raltegravir at a standard dose of 400 mg BID in a non-randomized open label study. Raltegravir was given in a number of different combinations with other antiretrovirals. 7 of the 22 women were on raltegravir prior to conception, 2 started...

The standard procedure to prevent the recurrence of hepatitis B after liver transplantation in patients infected with hepatitis B is the combination of a nucleoside or nucleotide with Hepatitis B Immune globulin (HBIg). The use of HBIg is both expensive and...

Pages