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In a French cohort of 3129 HIV-positive individuals a cross sectional investigation of the determinants of low CD4/CD8 ratio was performed. Individuals with stable antiretroviral therapy (ART) with plasma viral load less than 50 for at least two years were included...

Using records from the Veterans database of HCV infection (ERCHIVES) from 2001 to 2014, 9135 individuals who started HCV-therapy were identified. Of these 1649 developed cirrhosis and 239 developed HCC. The cumulative use of statins was measured (cumulative defined...

In a pilot study 17 patients with HAND were randomised to add Maraviroc to their present regimen or remain on their existing therapy. Patients with suspected HAND were evaluated with neuropsychological testing. Patients who scored below 1 standard deviation from the...

21 treatment naive and 20 treatment experienced patients with hepatitis C genotype 5 participated in a treatment trial of Ledipasvir/Sofosbuvir for 12 weeks in an open-label single arm French study. Nine of the 41 patients had cirrhosis. Eight of nine patients with...

In the national French (ANRS-EPF) cohort 8075 HIV-positive mothers were included from 2000 to 2011. The total number of transmissions from mother to child was 0.7 % (56/8075). In 2651 mothers who started ART before conception and had less than 50 copies/ml at the...

A Spanish cohort of HIV positive patients undergoing liver transplantation for hepatocellular cancer (HCC) were compared with matched patients undergoing liver transplantation for HCC without HIV infection. Patients were matched for age, gender, year of liver...

Baseline samples from patients participating in the Sapphire II and Turqouise II studies were analyzed with next generation sequencing (NGS) for RAV:s. All patients had genotype 1 a and were treated with ombitasvir/paritaprevir/ritonavir and dasabuvir together with...

34 patients with hepatitis C genotype 1 who had failed 4-6 weeks short courses of Ledipasvir/Sofosbuvir (LDV/SOF) treatment were retreated with the same regimen for 12 weeks. Deep sequencing was performed in all patients prior to retreatment. 29/34 patients had at...

In a meta-analysis of studies analyzing HCV relapse/reinfection after sustained viral response (SVR12/24) patients were divided into three categories; 1) Mono-infected “low risk” with no recognized risk factor, 2)Mono-infected “high risk” ( intravenous drug use or...

In a neurology substudy almost 600 patients were included. Neuropsychological testing was performed at baseline, after 4, 8, 12 months followed by annual testing. A quantitative neurocognitive performance z-score (QNPZ-8) was used. The QNPZ-8 scores rose in both the...

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