HIV and incidence of psoriasis


More than 20 000 Taiwanese adult patients who were diagnosed with HIV from 2000 until 2012 were followed for incident psoriasis for a median time of 5 years. A control group of more than 80,000 persons was matched for age and sex. During the follow up 252 cases of incident psoriasis were found. The incidence rate of psoriasis per 1,000 person-years was 0.80 in the HIV-positives and 0.37 in the matched control group. The difference is highly statistically significant (p < 0.001), hazard ratio 1.80 (1.38 – 2.36).

Yen et al. J Acquir Immune Defic syndrome 2017;75:493-499

Comment: Different skin disorders are more prevalent in
HIV-infected than in the general population. Immune dysregulation is often cited as the reason for the increased incidence of psoriasis in HIV infection. It is unclear if early antiretroviral treatment diminishes the incidence of psoriasis compared to late treatment and it is also not clear to what extent the absolute CD4 count influences the risk of psoriasis.